Olorofim - An Overview
While ectopic activation of mTORC1 in peripheral tissues is usually attained by administering a large dose of exogenous leucine, mTORC1 signaling from the CNS stays refractory probable due to the swift turnover and buffering of leucine during the brain18,19. The discovery of Sestrin1 and 2 as a specific leucine sensor upstream of mTORC1 offered a u